Star Trek: Federation Starships by BarkerC

In 2267, known ships in this class of heavy cruisers included the USS Constellation, the USS Defiant, the USS Excalibur, the USS Exeter, the USS Hood, the USS Lexington, and the USS Potemkin as well as several others.

Under command of Captain Styles during test flights, five years later, under the command of Captain Hikaru Sulu, she witnessed the explosion of the Klingon moon of Praxis and assisted the Enterprise in reaching the Khitomer Conference in time to prevent an assassination.

Having discovered the Bajoran wormhole, this runabout, named for a North American river, was the only Danube-class vessel stationed at Deep Space Nine to survive the entire run of the series.

The successful transmission of the EMH Mark-1 (aka The Doctor) to this prototype ship, NX-74913, compelled Starfleet to start the Pathfinder project to find USS Voyager in the Delta Quadrant. The EMH Mark 1, alongside the EMH Mark 2, helped defeat an attempted Romulan theft of the prototype.

In the Season 1 TNG episode "Conspiracy", art director Mike Okuda makes a nearly impossible to see in-joke by creating at least two starships based on other works of fiction. One is the USS Heart of Gold with registry number NCC-42. What literary character was honored with the name of the starship bearing the hull code NCC-221B?

Launched in 2154 and commanded by Captain Erika Hernandez, the NX-02 was the second NX project ship to be launched by the United Earth government. What name was given to this ship, fitting, as it's name also followed another prototype Enterprise 173 years earlier.

The name's the same: The NCC-1631 was a heavy cruiser crewed entirely by Vulcans, all of whom were killed by a giant space amoeba. The NCC-38907 was the ship on which Chief Petty Officer Sergey Rozhenko was serving when he adopted a young Klingon orphan. The NCC-74600 was the class ship of the first Federation starship to have variable geometry warp nacelles.

At the Second Battle of Chin'toka during the Dominion War, the USS Defiant was destroyed along with 99.6% of the overall Allied fleet gathered there. When Deep Space Nine was sent a replacement Defiant-class ship, it was given special dispensation to change its name from that of this South American city to USS Defiant. (presumably to save of visual effects costs.)

She was a Class 3 neutronic fuel carrier with home port of the vessel was Amber, Tau Ceti IV. The ship's master was Kojiro Vance when she struck a gravitic mine and its hull was breached, leading to a potentially dangerous rescue mission. Name her.

Named for the command module of the Apollo 13 mission, this Galaxy-class ship was lost during a 2370 battle in the Gamma Quadrant with the Jem'Hadar in the second season DS9 episode entitled "The Jem'Hadar".

In the alternate reality created by the detonation of a red matter device in 2387, this ship sees her captain murdered while negotiating with the commander of the Nerada, Nero, leaving Lt. Commander George Kirk in command of what vessel, registry number NCC-0514?

In a Chekov's gun* moment, in late 2366, Commander William T. Riker was offered command of this Excelsior-class starship, but turns it down. It will later be destroyed (in the same episode) by the Borg at the Battle of Wolf 359. *-(not that Chekov)